A hospital in the north-western Idlib province of Syria supported by Medecins Sans Frontieres (MSF) has been destroyed in a Russian air strike.
Syrian President Bashar al-Assad has said that he plans to retake “the whole country”, despite a renewed effort from the international community to push for peace.
Nations from around the globe have pledged $9bn (£6.2bn) in aid to help Syrians affected by the five-year conflict.
The Assad regime has agreed to permit the UN to deliver aid to the besieged rebel-held village of Madaya, following reports of villagers starving to death.
Russia is preparing to launch a range of sanctions against Turkey after a Turkish F-16 shot down a Russian jet near the Syrian border on Tuesday.